Dantrolene may prevent organophosphate-induced oxidative stress and muscle injury

作者：Buyukokuroglu Mehmet Emin^*; Cemek Mustafa; Tosun Murat; Yurumez Yusuf; Bas Orhan; Yavuz Yuecel

来源：Pesticide Biochemistry and Physiology, 2008, 92(3): 156-163.

DOI：10.1016/j.pestbp.2008.07.012

• Dantrolene
• Fenthion
• Muscle injury
• Organophosphate
• Oxidative stress

The effects of dantrolene against fenthion-incluced oxidative stress and muscle injury were investigated in rats. Malondialdehyde (MDA), reduced glutathione (GSH) ascorbic acid, retinol and beta-carotene levels in blood were measured. Histopathological alterations and apoptosis in diaphragm were examined. Fenthion increased the level of MDA and decreased the levels of GSH in blood. Dantrolene administration prevented the rise in MDA levels and increased the GSH levels. There was no significant difference between beta-carotene levels of experimental groups. However, fenthion toxicity led to decrease in ascorbic acid and retinol levels, dantrolene administration significantly prevented this decrease. Dantrolene significantly decreased the inflammation, edema and muscle necrosis or apoptosis in diaphragm muscle. Results of present study showed that toxicity of organophosphate compound fenthion increases the lipid peroxidation and depresses endogenous antioxidative systems, and leads to muscle injury in organism. Again, dantrolene administration prevents lipid peroxidation, augments antioxidant activity, and decreases muscle injury and apoptosis.

• 出版日期2008-11