Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata

作者：Uddin G^*; Sadat A; Siddiqui B S

来源：Tropical Biomedicine, 2014, 31(1): 143-148.

In the present study, the antioxidant and antiplasmodial activities of bergenin was compared with its natural derivative 11-O-galloylbergenin for the first time. Both compounds were isolated from Bergenia ligulata. 11-O-galloylbergenin was found to be very active in in-vitro antioxidant assay as compared to bergenin, which was found to be almost inactive. The EC50 values of 11-O-galloylbergenin were 7.45 +/- 0.2 mu g/mL and 5.39 +/- 0.28 mu g/mL in DPPH antioxidant assay and reducing power assay respectively, while IC50 value for antiplasmodial assay of both compounds were less than 2.5 mu M. Interestingly, in the total antioxidant phosphomolybdate assay, 11-O-galloylbergenin was found more potent (CAHT: 940.04 +/- 115.30) as compared to a-tocopherol (CAHT: 552.4 +/- 27.91).

• 出版日期2014-3