Alcoholism and Cellular Vulnerability in Different Brain Regions

作者：Skuja Sandra^*; Groma Valerija; Smane Liene

来源：Ultrastructural Pathology, 2012, 36(1): 40-47.

DOI：10.3109/01913123.2011.629770

• Alcohol
• electron microscopy
• myelin sheath
• prefrontal cortex
• striatum
• substantia nigra
• synapses

Alcohol-induced damage causes dysfunction of selected brain regions. Multidisciplinary studies have provided an extensive description of changes observed in neurons and glia following alcohol consumption. In this study the authors have elucidated preferential cellular vulnerability in three different brain regions. Autopsy material of the prefrontal cortex, striatum, and substantia nigra obtained from the brain tissue of alcoholic subjects was used in this study. We found that dendritic tree and astroglial damage is irreversible, while neuronal somata and most axons do not display irreversible changes.

• 出版日期2012-2