Vitamins A, C, and E May Reduce Intestinal 210Po Levels after Ingestion

作者：Kemp Francis W; Portugal Frank; Akudugu John M; Neti Prasad V S V; Ferraris Ronaldo P; Howell Roger W^*

来源：Health Physics, 2016, 111(1): 52-57.

DOI：10.1097/HP.0000000000000512

• Po-210
• adsorption
• biokinetics
• contamination
• internal

Damage to the gut mucosa is a probable contributory cause of death from ingested Po-210. Therefore, medical products are needed that can prevent, mitigate, and/or repair gastrointestinal (GI) damage caused by high-LET radiation emitted by Po-210. The present studies investigated the capacity of a diet highly enriched with vitamins A, C, and E (vitamin ACE) to protect against intestinal mucosal damage indicated by functional reductions in nutrient transport caused by orally ingested Po-210. Mice were gavaged with 0 or 18.5 kBq Po-210-citrate and fed a control or vitamin ACE-enriched diet (the latter beginning either 96 h before or immediately after gavage). Mouse intestines significantly retained Po-210 on day 8 post-gavage. The concentration of Po-210 in intestinal tissues was significantly (p<0.05) lower in all vitamin ACE groups compared to control. There were borderline significant Po-210-induced reductions in intestinal absorption of D-fructose. The combination of vitamins A, C, and E may reduce Po-210 incorporation in the intestines when given before, or enhance decorporation when provided after, Po-210 gavage.

• 出版日期2016-7