Herpes Simplex Virus is Akt-ing in translational control

作者：Norman Kara L; Sarnow Peter^*

来源：Genes & Development, 2010, 24(23): 2583-2586.

DOI：10.1101/gad.2004510

• Translational control
• herpesvirus replication
• viral kinase
• mTOR activation
• Akt signaling

All viruses depend on the cellular protein synthesis machinery for the production of viral proteins. Thus, viruses have evolved a variety of strategies to avoid innate host responses that inhibit protein synthesis. In this issue of Genes & Development, Chuluunbaatar and colleagues (pp. 2627-2639) demonstrate that Herpes Simplex Virus-1 counteracts this response through viral kinase Us3, which mimics cellular kinase Akt to phosphorylate and repress tuberous sclerosis complex 2 (TSC2), resulting in the activation of mammalian target of rapamycin complex 1 (mTORC1) and enhancement of mRNA translation.

• 出版日期2010-12-1