Antimalarial and antituberculosis substances from Streptomyces sp BCC26924

作者：Intaraudom Chakapong; Rachtawee Pranee; Suvannakad Rapheephat; Pittayakhajonwut Pattama^*

来源：Tetrahedron, 2011, 67(39): 7593-7597.

DOI：10.1016/j.tet.2011.07.053

• Actinomycetes
• Streptomyces
• Antimalaria
• Antituberculosis
• Carbazomycin derivatives
• Carbazomycin

Two new carbazomycin dimers (6 and 7) and 3-hydroxy-1,2-dimethyl-2,3-dihydro-1H-carbazol-4-one (9) together with six known compounds, carbazomycins A-D, cyclomarin C, and pimprinine have been isolated from Streptomyces sp. BCC26924. Carbazomycins B, C, and cyclomarin C exhibited antimalarial activity (against Plasmodium falciparum, K1 multi-drug resistant strain) with IC(50) in a range of 0.24-2.37 mu g/mL Cyclomarin C exhibited anti-TB activity with a minimum inhibitory concentration value of 0.10 mu g/mL, while carbazomycin D, compound 7, and pimprinine displayed MIC values in a range of 12.5-25.0 mu g/mL. In addition, compounds 2, 5, 6, and 7 showed weak cytotoxicity against cancerous (MCF-7, KB, NCI-H187) and non-cancerous (Vero) cells.

• 出版日期2011-9-30