Downregulation of GRIM-19 promotes growth and migration of human glioma cells

作者：Zhang, Yanmin; Hao, Hongbo; Zhao, Shidou; Liu, Qian; Yuan, Qiuhuan; Ni, Shilei; Wang, Fuwu; Liu, Shangming; Wang, Liyan; Hao, Aijun^*

来源：CANCER SCIENCE, 2011, 102(11): 1991-1999.

DOI：10.1111/j.1349-7006.2011.02059.x

• MATRIX METALLOPROTEINASES
• IN-VITRO
• CYCLE PROGRESSION
• SIGNAL TRANSDUCER
• IFN-BETA
• TUMOR
• GENE
• CLASSIFICATION
• EXPRESSION
• PROLIFERATION

It has become increasingly clear that there are notable parallels between normal development and tumorigenesis. Glioma is a classic model that links between tumorigenesis and development. We evaluated the expression of GRIM-19, a novel gene essential for normal development, in various grades of gliomas and several human glioma cell lines. We showed that GRIM-19 mRNA and protein expression were markedly lower in gliomas than in control brain tissues and negatively correlated with the malignancy of gliomas. Downregulation of GRIM-19 in glioma cells significantly enhanced cell proliferation and migration, whereas overexpression of GRIM-19 showed the opposite effects. We also showed that the activation of signal transducer and activator of transcription 3 (STAT3) and the expression of many STAT3-dependent genes were regulated by the expression of GRIM-19. In addition, GRIM-19 exerted its role probably through the non-STAT3 signaling pathway. Collectively, our data suggest that most gliomas expressed GRIM-19 at low levels, which may play a major role in tumorigenesis in the brain. (Cancer Sci 2011; 102: 1991-1999)

• 出版日期2011-11
• 单位山东大学