A new ent-kaurane diterpenoid from Isodon nervosus

作者:Yana FuLin*; Wang ChunMing; Gua LanQing; Zhang JiXia; Bai SuPing
来源:Journal of Chemical Research-S, 2008, (9): 522-524.
DOI:10.3184/030823408X349934

摘要

A new ent-kaurane diterpenoid, 6 beta,7 beta,13 alpha-trihydroxy-1 alpha-acetoxy-7 alpha,20-epoxy-ent-kaur-16-en-15-one (1) and five known compounds, epinodosinol (2), isodocarpin (3), nodosin (4), enmedol (5), nervosanin B (6), were isolated from the aerial part of Isodon nervosus. The structure of the new compound was determined by spectral methods (1D-,2D-NMR and MS). Four of the compounds were tested for their cytotoxicity towards HL60, SMMC-7721 and Hela cells.