Abnormal oral vascular network pattern geometry: A new clinical sign of Down syndrome

作者：Latini G^*; Bianciardi G; Parrini S; Laurini RN; De Felice C

来源：Journal of Pediatrics, 2006, 148(1): 132-137.

DOI：10.1016/j.jpeds.2005.08.049

Down syndrome is a leading genetic cause of mental retardation. Here, we show high fractal dimensions and Lempel-Ziv complexity and lower minimum path fractal dimension (P <= .0006) for the oral vascular networks of patients (n = 14) and their unaffected parents. This newly recognized sign may provide a useful phenotypical marker for identifying couples potentially at risk for offspring with Down syndrome.

• 出版日期2006-1