Diagnosis and Management of Pediatric Autoimmune Liver Disease: ESPGHAN Hepatology Committee Position Statement

作者：Mieli Vergani Giorgina^*; Vergani Diego; Baumann Ulrich; Czubkowski Piotr; Debray Dominique; Dezsofi Antal; Fischler Bjorn; Gupte Girish; Hierro Loreto; Indolfi Giuseppe; Jahnel Joerg; Smets Francoise; Verkade Henkjan J; Hadzic Nedim

来源：Journal of Pediatric Gastroenterology and Nutrition, 2018, 66(2): 345-360.

DOI：10.1097/MPG.0000000000001801

• autoimmune hepatitis
• autoimmune liver disease
• autoimmune sclerosing cholangitis
• children
• pediatric

Paediatric autoimmune liver disease is characterized by inflammatory liver histology, circulating autoantibodies, and increased levels of IgG, in the absence of a known etiology. Three conditions have a likely autoimmune pathogenesis: autoimmune hepatitis (AIH), autoimmune sclerosing cholangitis, and de novo AIH after liver transplantation. Two types of pediatric AIH are recognized according to seropositivity for smooth muscle and/or antinuclear antibody (AIH-1) or liver kidney microsomal type 1 and/or anti-liver cytosol type 1 antibodies (AIH-2).Pertinent issues addressing the diagnosis, treatment, and long-term follow-up were formulated by a core group of ESPGHAN members. They have commissioned the first authors with execution of this project. Initially, they have performed a systematic literature search on MEDLINE, ResearchGate, and Mendeley databases during the last 30 years and produced a document focusing on prospective and retrospective studies in children. The ESPGHAN core group and ESPGHAN Hepatology Committee members voted on each recommendation, using a formal voting technique.

• 出版日期2018-2