Asymmetric synthesis of 2-substituted cyclic amines

作者：Kudale Amit A^*; Anaspure Prasad; Goswami Falguni; Voss Matthew

来源：Tetrahedron Letters, 2014, 55(52): 7219-7221.

DOI：10.1016/j.tetlet.2014.11.022

• Asymmetric synthesis
• Cyclic amines
• Cyanomethylenetributylphosphorane
• Chiral auxiliary

Cyanomethylenetributylphosphorane-mediated ring closure for the asymmetric synthesis of 2-substituted cyclic amines such as azetidines, pyrrolidines and a piperidine is reported. The desired stereochemistry at the 2-position was fixed using (S)-tert-butyl sulfinamide as a chiral auxiliary.

• 出版日期2014-12-24