Antinociceptive efficacy and plasma concentrations of transdermal buprenorphine in dogs

作者：Pieper Korbinian^*; Schuster Tibor; Levionnois Olivier; Matis Ulrike; Bergadano Alessandra

来源：Veterinary Journal, 2011, 187(3): 335-341.

DOI：10.1016/j.tvjl.2010.01.013

• Buprenorphine
• Dog
• Thermal threshold
• Transdermal
• Antinociception

To assess the antinociceptive efficacy of transdermal (TD) buprenorphine (B) in dogs, a prospective, positive-controlled experimental study was performed in 10 healthy Beagles. In an open label crossover design, the dogs initially received intravenous B (IVB, 0.02 mg kg(-1)) as a positive control, followed by TDB (52.5 mu g h(-1)) 4 months later. Blood was collected at regular intervals for determination of the plasma concentrations of B ([B]) and its metabolite norbuprenorphine. The antinociceptive efficacy was assessed using thermal and mechanical models of nociception. The peak concentration [B] was 1.54 ng mL(-1) (+/- 1.98) 60 h after TDB application, although three dogs had no measurable [B] after TDB. Maximum thermal threshold (TT) was 52.6 degrees C (+/- 0.48) at 1 h after IVB administration and 51.63 degrees C (+/- 1.01) 72 h after TDB application. The significant increase in TT indicated that effective antinociception was achieved beyond 36 h after the application of TDB, lasting until patch removal. There was hysteresis between [B] and the antinociceptive effect.

• 出版日期2011-3