Arylation of Azaarylmethylamines with Aryl Chlorides and a NiBr2/NIXANTPHOS-based Catalyst

作者：Gao, Gui; Fu, Yue; Li, Minyan; Wang, Bo; Zheng, Bing^*; Hou, Shicong; Walsh, Patrick J.^*

来源：Advanced Synthesis & Catalysis, 2017, 359(16): 2890-2894.

DOI：10.1002/adsc.201700438

• NIXANTPHOS
• NiBr2
• Arylation
• Azaarylmethylamines
• Aryl Chlorides

A nickel-catalyzed coupling of azaarylmethylamines with aryl chlorides has been achieved. NIXANTPHOS together with low cost NiBr2 was successfully developed and optimized to exhibit high reactivity at 2.5 mol% loading. Under optimized reaction conditions, aryl(azaaryl)methylamine products were afforded in good to excellent yields (22 examples, up to 98% yield).

• 出版日期2017-8-17
• 单位中国农业大学