A pilot psychometric study of aberrant salience state in patients with Parkinson's disease and its association with dopamine replacement therapy

作者：Poletti Michele^*; Frosini Daniela; Pagni Cristina; Baldacci Filippo; Lucetti Claudio; Del Dotto Paolo; Ceravolo Roberto; Bonuccelli Ubaldo

来源：Neurological Sciences, 2014, 35(10): 1603-1605.

DOI：10.1007/s10072-014-1874-6

• Parkinson's disease
• Aberrant salience
• Dopamine overdose
• Levodopa
• Dopamine agonists
• Psychosis

An overactive striatal dopaminergic neurotransmission is described in psychosis and may be associated with a state of aberrant salience attribution. This pilot psychometric study investigated if features suggestive of an aberrant salience state, a condition of psychosis proneness, are associated with dopamine replacement therapy in patients with early Parkinson's disease (PD). 77 participants (50 medicated PD patients, 12 newly diagnosed drug-naive PD patients and 15 healthy controls) were enrolled and assessed with the Aberrant Salience Inventory (ASI). Differences between groups were found for ASI scores, and ASI scores correlated with the dopaminergic therapy, in particular levodopa. These findings preliminary suggested that the presence and the degree of an aberrant salience state may be associated with features of the dopaminergic therapy; further studies are needed to investigate which neuropsychiatric complications more common in PD patients may be characterized by an underlying aberrant salience state.

• 出版日期2014-10