Highly efficient copper catalytic system for the O-arylation of phenol with iodoarene

作者：Cheng An Yi; Hsieh Jen Chieh^*

来源：Tetrahedron Letters, 2012, 53(1): 71-75.

DOI：10.1016/j.tetlet.2011.10.149

• Cu2O
• Ullmann coupling
• 1H-imidazole-4-carboxylic acid
• Diaryl ether
• O-arylation

An efficient Cu-catalyzed O-arylation was carried out by involving phenols with iodoarenes to afford various substituted diarylether derivatives with tiny loading of Cu2O and 1H-imidazole-4-carboxylic acid as catalytic system under mild conditions, which provided good to excellent yields with good tolerance of functional groups.

• 出版日期2012-1-4