Marked elevation of urinary beta 2-microglobulin in patients with reversible splenial lesions: A small case series

作者：Azuma Junji; Nabatame Shin; Katsura Toshiya; Yamamoto Kyoko; Kaneno Hiroshi; Kijima Eri; Mizoguchi Yoshimi; Shimotsuji Tunesuke; Yamamoto Takehisa; Ozono Keiichi

来源：Journal of the Neurological Sciences, 2016, 368: 109-112.

DOI：10.1016/j.jns.2016.06.066

• Reversible splenial lesion syndrome
• Mild encephalopathy with a reversible splenial lesion
• Cytokine
• beta 2-Microglobulin
• Encephalitis

The magnetic resonance imaging findings of reversible isolated lesions with transiently reduced diffusion in the splenium of corpus callosum of patients with a wide spectrum of pathological conditions are referred to as reversible splenial lesion syndrome (RESLES). Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is probably included within the spectrum of RESLES; however, its exact pathophysiology is not known. Here, we describe three patients with MERS and one patient with RESLES, all of whom showed elevated urinary beta 2-microglobulin regardless of diagnosis and presence of pathogens. Elevated urinary beta 2-microglobulin suggested that an excessive immune response might play a role in the pathophysiology of reversible splenial lesions.

• 出版日期2016-9-15