A novel porous natural polymer scaffold for tissue engineering

作者：Gong, Shengju; Dong, Jian; Xue, Song Tao; Wang, Jin Ye^*

来源：27th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, China,Shanghai, 2005-08-31 to 2005-09-03.

• porous scaffold
• mechanical properties
• porosity
• cytocompatility

A novel porous polymer scaffold fabricated by salt-leaching method for tissue engineering was developed and the mechanical properties and porosity were investigated in our study. Scanning electronic microscopy (SEM) was employed to observe the morphology and structure of porous scaffolds. Cytocompatility of the porous scaffolds were evaluated, using HL-7702 cells as model, in terms of cell attachment and cell viabilities from 3 to 72 hours determined by MTT method. Result: These scaffolds possessed a total porosity of 64.2%, compressive Young's modulus of (31.8 +/- 6.5) Mpa. The particle size of porogen has little effect on the compressive properties and porosities. In addition, the morphology of pores observed by SEM showed good pore interconnectivity within the porous scaffolds. HL-7702 cell viabilities kept at high level during the whole incubation period.

• 出版日期2005
• 单位上海交通大学