A New C-29-sterol with a Cyclopropane Ring at C-25 and 26 from the Vietnamese Marine Sponge Ianthella sp.

作者：Nguyen Huu Tung; Chau Van Minh; Phan Van Kiem; Hoang Thanh Huong; Tran Thu Ha; Nguyen Tien Dat; Nguyen Xuan Nhiem; Nguyen Xuan Cuong; Hyun Jae Hee; Kang Hee Kyoung; Kim Young Ho^*

来源：Archives of Pharmacal Research, 2009, 32(12): 1695-1698.

DOI：10.1007/s12272-009-2205-y

• Sponge
• Ianthella sp.
• Sterol
• Aragusteroketal B
• Cytotoxic activity

One new C-29 sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC50 in the range of 12.8-27.8 mu M.

• 出版日期2009-12
• 单位河北医科大学