Usefulness of F-18 Florbetaben in Diagnosis of Alzheimer%26apos;s Disease and Other Types of Dementia

作者：Chiaravalloti Agostino; Danieli Roberta; Lacanfora Annamaria; Palumbo Barbara; Caltagirone Carlo; Schillaci Orazio

来源：Current Alzheimer Research, 2017, 14(2): 154-160.

DOI：10.2174/1567205013666160620114309

• Amyloid
• Alzheimer's disease
• florbetaben
• PET
• mild cognitive impairment

In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron mission Tomography (PET). Among these, F-18 Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties that make it usable in common clinical routine.
The aim of this review is to provide a general overview of the application in vivo of F-18 Florbetaben, describing for first the physiopathological basis of amyloid pathology. Afterwards, the chemical characteristics of this radiolabeled compound will be described, with a particular attention to the synthesis process and the kinetic in vivo. An overview on the imaging protocols and image interpretation will be provided as well and, as a last aspect, the results of the main studies performed in subjects with advanced and early AD will be summarized.

• 出版日期2017
• 单位Perugia