Decidual infiltration of FoxP3(+) regulatory T cells, CD3(+) T cells, CD56(+) decidual natural killer cells and Ki-67 trophoblast cells in hydatidiform mole compared to normal and ectopic pregnancies

作者：Sundara Yayan T^*; Jordanova Ekaterna S; Hernowo Bethy S; Gandamihardja Supriadi; Fleuren Gert Jan

来源：Molecular Medicine Reports, 2012, 5(1): 275-281.

DOI：10.3892/mmr.2011.633

• CD3(+) T cells
• CD56(+)
• ectopic pregnancy
• hydatidiform mole
• FoxP3(+) regulatory T cells

Hydatidiform moles are considered pre-cancerous lesions of gestational trophoblastic neoplasia and are associated with an berrant immune response. This preliminary study aimed to Evaluate the feasibility of measuring the presence of immune :ells as potential prognostic markers for hydatidiform moles. Immunohistochemical staining of FoxP3(+) regulatory T cells, CD3(+) T cells, CD56(+) decidual natural killer cells and trobhoblast cells was performed on 32 samples. Samples were fro complete hydatidiform moles, partial hydatidiform moles, e topic pregnancies, gestational age-matched normal elective pregnancy terminations (normal pregnancies) and gestational trophoblastic neoplasias. FoxP3(+) regulatory T-cell infiltration was highest in the complete hydatidiform moles and low est in the normal pregnancy samples. The normal pregnancy cases showed significantly fewer Fox P3(+). regulatory T cells compared to the ectopic pregnancy cases (p=0.037) and compared to the combination of all of the other groups (p=0.04-.). Normal pregnancy samples also showed the lowest infiltration of CD3(+) T cells and the highest number of CD56(+) decidual natural killer cells; conversely, gestational trophoblastic neoplasias showed the highest infiltration of CD3(+). T cells a id the lowest number of CD56+ decidual natural killer cells. Th; numbers of Ki-67(+) trophoblast cells were highest in the gestational trophoblastic neoplasias (688/1,000 trophoblast cells) at I lowest in the partial moles (87/1,000 trophoblast cells). Our results suggest that regulatory T cells may be involved in the progression of complete hydatidi form moles. A larger cohort study is required to assess whether immune cells are effective prognostic markers in gestational trophoblastic diseases.

• 出版日期2012-1