Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine

作者：Xiong, Yongzhen; Chen, Shengli; Chen, Ruhong; Lin, Weiyan; Ni, Jindong^*

来源：Human Vaccines & Immunotherapeutics, 2013, 9(8): 1673-1678.

DOI：10.4161/hv.24938

• polymorphisms
• miRNA
• hepatitis B vaccine
• antibody
• immune response

To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-146a, miR-196a2, miR-27a, miR-26a-1, miR-124 and miR-149 genes are associated with immune response to hepatitis B vaccine. The genotype and allele frequencies of SNPs were compared between the non-responders (n = 77) and responders (n = 207). The associations of the genotypes with antibody levels were assessed in the responders. Significant associations were observed between SNPs in miR-146a and miR-26a-1 genes and non-response to hepatitis B vaccine (p < 0.05). In addition, SNPs in miR-146a and miR-27a genes were associated with variations in levels of antibodies to hepatitis B antigen. Thus, specific SNPs in microRNAs (miRNAs) genes may affect status of the hepatitis B vaccine induced protective humoral immune response. They also suggest that the three miRNAs play a role in modulating antibody responses to hepatitis B vaccine.

• 出版日期2013-8-1
• 单位南方医科大学; 广东医科大学