alpha-Glucosidase inhibiting activity and bioactive compounds of six red wine grape pomace extracts

作者：Kadouh Hoda C; Sun Shi; Zhu Wenjun; Zhou Kequan^*

来源：Journal of Functional Foods, 2016, 26: 577-584.

DOI：10.1016/j.jff.2016.08.022

• Diabetes
• Grape pomace
• Phenolics
• Mammalian intestinal
• alpha-glucosidase

Grape pomace contains considerable amounts of polyphenols and it has been reported to exhibit specific inhibitory activity against mammalian intestinal alpha-glucosidases. This study aims to investigate the anti-diabetes potential of Chambourcin, Merlot, Norton, Petit Verdot, Syrah and Tinta Cao red wine grape pomaces by assessing their rat intestinal alpha-glucosidase inhibitory activity in relation to their total phenolic content and individual identified phenolic compounds by HPLC. Among the selected pomaces, Tinta Cab, Syrah and Merlot extracts showed higher potency in inhibiting alpha-glucosidase, and appeared to have higher respective total phenolic contents. Fifteen phenolic compounds were identified in the pomace samples, however, none of them showed significant inhibition of intestinal alpha-glucosidases. Red grape pomace, namely Tinta Cao, appears to be a promising functional food for the potential future development of a food-derived alpha-glucosidase inhibitor for preventing and treating diabetes.

• 出版日期2016-10