New Benzoxazine Secondary Metabolites from an Arctic Actinomycete

作者：Moon Kyuho; Ahn Chan Hong; Shin Yoonho; Won Tae Hyung; Ko Keebeom; Lee Sang Kook; Oh Ki Bong; Shin Jongheon; Nam Seung Il; Oh Dong Chan^*

来源：Marine Drugs, 2014, 12(5): 2526-2538.

DOI：10.3390/md12052526

• Arctic
• marine actinomycete
• secondary metabolite
• benzoxazine
• C-1027
• fijiolides
• disaccharide
• isocitrate lyase

Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (3-5) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures of 1 and 2 were elucidated through NMR, mass, UV, and IR spectroscopy. The hexose moieties in 1 were determined to be D-glucose from a combination of acid hydrolysis, derivatization, and gas chromatographic analyses. Arcticoside (1) and C-1027 chromophore-V (2), which have a benzoxazine ring, inhibited Candida albicans isocitrate lyase. Chromophore-V (2) exhibited significant cytotoxicity against breast carcinoma MDA-MB231 cells and colorectal carcinoma cells (line HCT-116), with IC50 values of 0.9 and 2.7 mu M, respectively.

• 出版日期2014-5
• 单位中国极地研究中心