Association of baseline sex hormone levels with baseline and longitudinal changes in waist-to-hip ratio: Multi-Ethnic Study of Atherosclerosis

作者：Vaidya D^*; Dobs A; Gapstur S M; Golden S H; Cushman M; Liu K; Ouyang P

来源：International Journal of Obesity, 2012, 36(12): 1578-1584.

DOI：10.1038/ijo.2012.3

• sex hormones
• epidemiology
• waist-to-hip ratio

OBJECTIVE: Waist-to-hip ratio (WHR) is strongly associated with prevalent atherosclerosis. We analyzed the associations of baseline serum levels of testosterone (T), estradiol (E2), sex-hormone-binding globulin (SHBG) and dehydroepiandrosterone (DHEA) with WHR in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. %26lt;br%26gt;SUBJECTS: Baseline data was available for 3144 men and 2038 postmenopausal women, who were non-users of hormone therapy, who were 45-84 years of age, and of White, Chinese, Black or Hispanic racial/ethnic groups. Of these, 2708 men and 1678 women also had longitudinal measurements of WHR measured at the second and/or the third study visits (median follow-up 578 days and 1135 days, respectively). %26lt;br%26gt;RESULTS: In cross-sectional analyses adjusted for age, race and cardiovascular disease risk factors, T was negatively associated with baseline WHR in men, whereas in both sexes, E2 was positively associated and SHBG was negatively associated with WHR (all P%26lt;0.001). In longitudinal analyses, further adjusted for follow-up time and baseline WHR, baseline T was negatively associated with WHR at follow-up (P = 0.001) in men, whereas in both sexes, E2 was positively associated (P = 0.004) and SHBG was negatively associated with WHR (P%26lt;0.001). The longitudinal association of E2, but not T, was independent of SHBG. In cross-sectional or longitudinal analyses, there were no associations between DHEA and WHR in either men or women. %26lt;br%26gt;CONCLUSION: Sex hormones are associated with WHR at baseline and also during follow-up above and beyond their baseline association. Future research is needed to determine if manipulation of hormones is associated with changes in central obesity. International Journal of Obesity (2012) 36, 1578-1584; doi:10.1038/ijo.2012.3; published online 24 January 2012

• 出版日期2012-12
• 单位西北大学