Analysis of polymorphism rs1990760 of IFIH1 gene and treatment outcomes in HCV infection

作者：Iqbal Muhammad Sarfaraz^*; Ashfaq Usman Ali; Aslam Sadia; Khaliq Saba; Ghani Muhammad Usman; Batool Farzana

来源：Future Virology, 2018, 13(3): 181-187.

DOI：10.2217/fvl-2017-0116

• HCV
• IFH1
• MDA-5
• RIG-like helicases
• rs1990760

Hepatitis C virus (HCV) is endemic in Pakistan, infecting approximately 12 million people and expected to increase in the coming decades. IFIH1 is a viral RNA sensor gene essential for the activation of innate immunity against RNA viruses. Aim: The aim of the study was to analyze the association of the polymorphism (rs1990760) in IFIH1 gene among HCV infected Pakistani patients and healthy controls. Materials & methods: Blood samples from 400 chronic HCV patients (including 323 responders and 77 nonresponders) and 100 healthy individuals were collected. Results: Frequencies of heterozygous computed tomography genotype significantly associated with decreased HCV risk (chi(2) = 0.072; 95% Cl: 1.06; 0.68-1.65; p <= 0.788). Conclusion: No significant differences were observed in alleles and genotype frequencies of IFIH1 (rs1990760) in Pakistani HCV infected patients.

• 出版日期2018-3