Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs

作者:Xiao Wang; Zeng Xuan; Lin Hang; Han Kai; Jia Hui Zhen; Zhang Xian Zheng*
来源:Chemical communications, 2015, 51(8): 1475-1478.
DOI:10.1039/c4cc08831j

摘要

A dual stimuli-responsive multi-drug delivery system was developed for "cancer cocktail therapy". Upon UV irradiation, microcapsules could rapidly release the small-molecule drugs, and thereafter the macromolecular drugs would be released in the presence of MMP in the tumor cells. This system will find great potential as a novel chemotherapeutic combination for cancer treatment.