Application of optically active aminonaphthols as NMR solvating agents for chiral discrimination of mandelic acid

作者：Chaudhary Anju R; Yadav Priyanka; Bedekar Ashutosh V^*

来源：Tetrahedron: Asymmetry , 2014, 25(9): 767-774.

DOI：10.1016/j.tetasy.2014.04.003

A series of optically active aminonaphthol derivatives were prepared and screened as chiral solvating agents to discriminate the (CH)-H-alpha of racemic mandelic acid by H-1 NMR analysis. An effort was made to establish a correlation of the structure of aminonaphthol derivatives and the selectivity in this non-covalent interaction. A linear relationship between the experimental and calculated enantiomeric purity was established by indicating the potential use of the system to determine the ee for the samples of mandelic acid of unknown enantiomeric purity.

• 出版日期2014-5-15