Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8 '-hydroxylase CYP707A

作者：Okazaki Mariko; Nimitkeatkai Hataitip; Muramatsu Taku; Aoyama Hikaru; Ueno Kotomi; Mizutani Masaharu; Hirai Nobuhiro; Kondo Satoru; Ohnishi Toshiyuki; Todoroki Yasushi^*

来源：Bioorganic & Medicinal Chemistry, 2011, 19(1): 406-413.

DOI：10.1016/j.bmc.2010.11.011

• Plant growth regulator
• P450 inhibitor
• ABA

We developed abscinazole-E1 (Abz-E1), a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase (CYP707A). This inhibitor was designed and synthesized as an enlarged analogue of uniconazole (UNI), a well-known plant growth retardant, which inhibits a gibberellin biosynthetic enzyme (ent-kaurene oxidase, CYP701A) as well as CYP707A. Our results showed that Abz-E1 functions as a potent inhibitor of CYP707A and a poor inhibitor of CYP701A both in vitro and in vivo. Abz-E1 application to plants resulted in improved desiccation tolerance and an increase in endogenous ABA.

• 出版日期2011-1-1