AN EFFICIENT SYNTHESIS OF 1-HYDROXY-5,8-DIMETHOXY-2-NAPHTHALDEHYDE

作者:Zhang, Qijing; Dong, Jinyun; Huang, Guang; Li, Shaoshun*
来源:Heterocycles, 2018, 96(2): 334-338.
DOI:10.3987/COM-17-13859

摘要

An efficient method for the preparation of 1-hydroxy-5, 8-dimethoxy-2-naphthaldehyde (1) was developed with a high overall yield (73.8%). Compared with the previously reported method, the reaction conditions are milder and the work-up of each step is much simpler. Moreover, the starting material considerably reduces the cost and is suitable for large-scale preparations.

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