Nitric oxide affects short-term olfactory memory in the antennal lobe of Manduca sexta

作者：Gage Stephanie L^*; Daly Kevin C; Nighorn Alan

来源：Journal of Experimental Biology, 2013, 216(17): 3294-3300.

DOI：10.1242/jeb.086694

• olfaction
• learning
• memory
• circadian
• NOS inhibition
• moth

Nitric oxide (NO) is thought to play an important neuromodulatory role in olfaction. We are using the hawkmoth Manduca sexta to investigate the function of NO signaling in the antennal lobe (AL; the primary olfactory network in invertebrates). We have found previously that NO is present at baseline levels, dramatically increases in response to odor stimulation, and alters the electrophysiology of AL neurons. It is unclear, however, how these effects contribute to common features of olfactory systems such as olfactory learning and memory, odor detection and odor discrimination. In this study, we used chemical detection and a behavioral approach to further examine the function of NO in the AL. We found that basal levels of NO fluctuate with the daily light cycle, being higher during the nocturnal active period. NO also appears to be necessary for short-term olfactory memory. NO does not appear to affect odor detection, odor discrimination between dissimilar odorants, or learning acquisition. These findings suggest a modulatory role for NO in the timing of olfactory-guided behaviors.

• 出版日期2013-9