Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor

作者：Walzer Thierry; Chiossone Laura; Chaix Julie; Calver Andrew; Carozzo Claude; Garrigue Antar Laure; Jacques Yannick; Baratin Myriam; Tomasello Elena; Vivier Eric^*

来源：Nature Immunology, 2007, 8(12): 1337-1344.

DOI：10.1038/ni1523

Consistent with their function in immune surveillance, natural killer (NK) cells are distributed throughout lymphoid and nonlymphoid tissues. However, the mechanisms governing the steady-state trafficking of NK cells remain unknown. The lysophospholipid sphingosine 1-phosphate (S1P), by binding to its receptor S1P(1), regulates the recirculation of T and B lymphocytes. In contrast, S1P(5) is detected in the brain and regulates oligodendrocyte migration and survival in vitro. Here we show that S1P(5) was also expressed in NK cells in mice and humans and that S1P(5)- deficient mice had aberrant NK cell homing during steady-state conditions. In addition, we found that S1P(5) was required for the mobilization of NK cells to inflamed organs. Our data emphasize distinct mechanisms regulating the circulation of various lymphocyte subsets and raise the possibility that NK cell trafficking may be manipulated by therapies specifically targeting S1P(5).

• 出版日期2007-12