Nanostructured Boron Nitride With High Water Dispersibility For Boron Neutron Capture Therapy

作者：Singh Bikramjeet; Kaur Gurpreet; Singh Paviter; Singh Kulwinder; Kumar Baban; Vij Ankush; Kumar Manjeet; Bala Rajni; Meena Ramovatar; Singh Ajay; Thakur Anup; Kumar Akshay

来源：Scientific Reports, 2016, 6(1): 35535.

DOI：10.1038/srep35535

Highly water dispersible boron based compounds are innovative and advanced materials which can be used in Boron Neutron Capture Therapy for cancer treatment (BNCT). Present study deals with the synthesis of highly water dispersible nanostructured Boron Nitride (BN). Unique and relatively low temperature synthesis route is the soul of present study. The morphological examinations (Scanning/transmission electron microscopy) of synthesized nanostructures showed that they are in transient phase from two dimensional hexagonal sheets to nanotubes. It is also supported by dual energy band gap of these materials calculated from UV-visible spectrum of the material. The theoretically calculated band gap also supports the same (calculated by virtual nano lab Software). X-ray diffraction (XRD) analysis shows that the synthesized material has deformed structure which is further supported by Raman spectroscopy. The structural aspect of high water disperse ability of BN is also studied. The ultra-high disperse ability which is a result of structural deformation make these nanostructures very useful in BNCT. Cytotoxicity studies on various cell lines (Hela(cervical cancer), human embryonic kidney (HEK-293) and human breast adenocarcinoma (MCF-7)) show that the synthesized nanostructures can be used for BNCT.

• 出版日期2016-10-19