A Mitochondrial Checkpoint in Autoimmune Disease

作者:Weyand Cornelia M*; Goronzy Jorg J
来源:Cell Metabolism, 2018, 28(2): 185-186.
DOI:10.1016/j.cmet.2018.07.014

摘要

Cell-fate decisions in innate and adaptive immune cells are metabolically regulated and modified by tissuederived signals, thereby balancing protective and pathogenic immunity. Reporting in Science, Ling et al. (2018) have identified C1q as a mitochondrial activator that suppresses exuberant anti-self and anti-viral CD8 T cell effector responses to prevent autoimmune disease.

  • 出版日期2018-8-7