Association of Dyslipidemia with Renal Cell Carcinoma: A 1:2 Matched Case-Control Study

作者：Zhang, Chunfang; Yu, Luping; Xu, Tao^*; Hao, Yichang; Zhang, Xiaowei; Liu, Zhenhua; Xiao, Yunbei; Wang, Xiaofeng; Zeng, Qiang

来源：PLos One, 2013, 8(3): e59796.

DOI：10.1371/journal.pone.0059796

• DENSITY-LIPOPROTEIN CHOLESTEROL
• KIDNEY CANCER
• RISK-FACTORS
• MALE SMOKERS
• COHORT
• HDL
• HYPOCHOLESTEROLEMIA
• MORTALITY
• DISEASE
• DIETARY

Abnormal serum lipid profiles are associated with the risk of some cancers, but the direction and magnitude of the association with renal cell carcinoma is unclear. We explore the relationship between serum lipids and renal cell carcinoma via a matched case-control study. A 1:2-matched case-control study design was applied, where one renal cell carcinoma patient was matched to two non-renal-cell-carcinoma residents with respect to age (+/- 0 year) and gender. Cases (n = 248) were inpatients with a primary diagnosis of renal cell carcinoma, confirmed by pathology after operations. Controls were sampled from a community survey database matched on age and gender with cases, 2 controls for each case. Stratified Cox proportional hazard regression analysis was used to obtain hazard ratios and corresponding 95% confidence intervals of lipids level and dyslipidemia for the risk of renal cell carcinoma. Elevated serum cholesterol (p < 0.001), LDL cholesterol (p < 0.001), and HDL cholesterol (p = 0.003) are associated with decreased hazard of renal cell carcinoma, adjusting for obesity, smoke, hypertension and diabetes. However, risk caused by hTG showed no statistical significance (p = 0.263). This study indicates that abnormal lipid profile influences the risk of renal cell carcinoma.

• 出版日期2013-3-25
• 单位北京大学; 中国人民解放军总医院