科研之友
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摘要
Primary mechanism of a Pd-II-catalyzed 8-aminoquinoline-directed C-H alkoxylation was investigated. It was understood that the Pd-II-catalyzed C(sp(3))-O bond formation proceeded through a concerted reductive elimination from the Pd-IV intermediate in the cyclic system. Deuteration experiments and related computational studies elucidate that intrinsic conformation determined the diastereoselectivity of the Pd-II-catalyzed C-H alkoxylation of cyclic carboxylic acids.
- 出版日期2016-3-1
- 单位北京大学深圳研究生院; 清华大学
