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摘要
A fully validated, sensitive and precise stability-indicating square-wave adsorptive cathodic stripping voltammetric method has been developed for determination of gatifloxacin in the bulk form, pharmaceutical formulation, and in spiked human serum and real plasma samples. The achieved detection limits of gatifloxacin in the bulk form and human serum were 1.5 x 10(-9) and 2.2 x 10(-9) mol L(-1), respectively. The described method was applied successfully for determination of gatifloxacin in formulation and human biological samples without extraction prior to the analysis. No significant interferences from common excipients, some common metal ions, organic species, co-administrated drugs and from the acid-induced degradation products were obtained during analysis of gatifloxacin in the various analyzed samples. Besides, pharmacokinetic parameters of gatifloxacin in plasma of healthy volunteers following the administration of an oral single dose (400 mg gatifloxacin) were also estimated by means of the described stripping voltammetric method.
- 出版日期2009
