A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis

作者：Kim Hyejin; Rather Irfan A; Kim Hyunwook; Kim Sungsoo; Kim Taeeun; Jang Jaeyoung; Seo Jimin; Lim Jeongheui; Park Yong Ha^*

来源：Journal of Microbiology and Biotechnology, 2015, 25(11): 1966-1969.

DOI：10.4014/jmb.1506.06065

• Canine atopic dermatitis
• Lactobacillus sakei
• probiotics
• skin disorder

Canine atopic dermatitis (CAD) is a ubiquitous, chronic inflammatory skin disorder prevalent in dogs, which results in production of abnormal levels of IgE antibodies in reciprocation to an allergen challenge. In this study, administration of the probiotic strain Lactobacillus sakei probio-65 for 2 months significantly reduced the disease severity index in experimental dogs diagnosed with CAD. In addition, one month pre-medication of L. sakei probio-65 revealed significant difference in the PVAS score in experimental dogs for both probio-65 and placebo groups. However, post 2 months treatment resulted in a significant decrease in the CASESI score values in the probio-65-treated group (p < .0.06).

• 出版日期2015-11