Negative Amyloid PET Imaging in a Patient With Probable Alzheimer's Disease

作者：Hellwig Sabine^*; Huell Michael; Meyer Philipp T

来源：Clinical Nuclear Medicine, 2011, 36(12): 1120-1121.

DOI：10.1097/RLU.0b013e3182335e08

• positron emission tomography
• C-11 PIB
• biomarker
• Alzheimer's disease

Amyloid positron emission tomography (PET) has emerged as an in vivo technique for visualizing the accumulation of fibrillar amyloid-beta (A beta). Carbon-11 Pittsburgh compound-B (C-11 PIB) has gained widespread acceptance as a standard amyloid PET probe. We report a case of a 53-year-old woman with probable Alzheimer's disease (AD) confirmed by neuropsychological assessment and cerebrospinal fluid analyses. Fluorine-18 fluorodeoxyglucose PET depicted an AD-typical pattern of cortical hypometabolism. Unexpectedly, C-11 PIB PET detected no cortical A beta depositions. The present case challenges the notion that a negative C-11 PIB scan excludes AD and argues for a comprehensive diagnostic workup.

• 出版日期2011-12