Hemoglobin A(1c) and Fructosamine for Assessing Glycemic Control in Diabetic Patients With CKD Stages 3 and 4

作者：Chen Harn Shen^*; Wu Tzu En; Lin Hong Da; Jap Tjin Shing; Hsiao Li Chuan; Lee Shen Hung; Lin Shu Hsia

来源：American Journal of Kidney Diseases, 2010, 55(5): 867-874.

DOI：10.1053/j.ajkd.2009.10.064

• Hemoglobin A(1c)
• fructosamine
• diabetes
• chronic kidney disease

Background: Hemoglobin A(1c) (HbA(1c)) and fructosamine can be used to monitor glycemic control in diabetic patients with normal kidney function, but their validity in patients with chronic kidney disease (CKD) has not been evaluated. In this study, we evaluated the correlation and accuracy of these 2 measures of glycemic control in type 2 diabetic patients with CKD stages 3-4.
Study Design: Diagnostic test study.
Setting & Participants: Type 2 diabetic patients with normal (n = 30) and abnormal kidney n = 30) were recruited in Taipei Veterans General Hospital, Taiwan.
Index Tests: HbA(1c) and fructosamine.
Reference Test: Self-monitoring of blood glucose levels.
Measurements: Blood glucose measurements consisted of 6 preprandial, 6 postprandial, and 2 bedtime assessments in a week with a cycle of 4-week intervals for 12 weeks.
Results: Correlation coefficients between HbA(1c) level or fructosamine-albumin ratio and mean blood glucose levels were 0.836 and 0.645 in participants with normal kidney function and 0.813 and 0.649 in participants with CKD stages 3-4, respectively. In patients with CKD stages 3-4, mean blood glucose levels in weeks 1-12 were 21.9 mg/dL (95% CI, 11.6-32.5) higher than estimated average glucose (eAG) levels calculated from HbA(1c) levels in participants with normal kidney function. In patients with CKD stages 3-4, mean blood glucose levels in weeks 10-12 were 15.5 mg/dL (95% CI, 5.2-30.5) higher than eAG levels calculated from fructosamine levels in participants with normal kidney function, but without statistical significance when eAG calculated from fructosamine level was corrected for serum albumin level (difference of 5.6 mg/dL; 95% CI, -8.6 to 19.8).
Limitations: Relatively small number of participants with limited amount of blood glucose measurement data.
Conclusion: Our data show that eAG calculated from HbA(1c) and fructosamine levels might underestimate mean blood glucose levels in patients with CKD stages 3-4. References ranges may need to be modified when interpreting results of measurements of glycemic control in type 2 diabetic patients with CKD. Am J Kidney Dis 55: 867-874.

• 出版日期2010-5