Potassium iodide catalyzed reductive dehalogenation of alpha-halo-ketones using Hantzsch ester diethyl 1, 4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate as reductant

作者：Li, Hong Sheng; Li, Yi Qun^*

来源：Chinese Chemical Letters, 2010, 21(8): 931-934.

DOI：10.1016/j.cclet.2010.03.027

• Dehalogenation
• alpha-Halo ketones
• Hantzsch ester
• 1,4-Dihydro-2,6-dimethylpyridine-3,5-dicarboxylate
• Potassium iodide

In the presence of diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (DHP) and a catalytic amount of potassium iodide, several alpha-halo ketones were easily reduced to the corresponding ketones in acetone media. The procedure presented here showed several merits such as short reaction time, practical experimental and isolated procedure, and excellent yields of products.

• 出版日期2010-8
• 单位暨南大学