Fabrication of All Glass Bifurcation Microfluidic Chip for Blood Plasma Separation

作者：Jang Hyungjun; Haq Muhammad Refatul; Ju Jonghyun; Kim Youngkyu; Kim Seok min; Lim Jiseok

来源：Micromachines, 2017, 8(3): 67.

DOI：10.3390/mi8030067

• glass molding
• amorphous carbon mold
• microfluidics
• blood plasma separation
• bifurcation microfluidic chip

An all-glass bifurcation microfluidic chip for blood plasma separation was fabricated by a cost-effective glass molding process using an amorphous carbon (AC) mold, which in turn was fabricated by the carbonization of a replicated furan precursor. To compensate for the shrinkage during AC mold fabrication, an enlarged photoresist pattern master was designed, and an AC mold with a dimensional error of 2.9% was achieved; the dimensional error of the master pattern was 1.6%. In the glass molding process, a glass microchannel plate with negligible shape errors (similar to 1.5%) compared to AC mold was replicated. Finally, an all-glass bifurcation microfluidic chip was realized by micro drilling and thermal fusion bonding processes. A separation efficiency of 74% was obtained using the fabricated all-glass bifurcation microfluidic chip.

• 出版日期2017-3