Antioxidant, antimelanogenic, and skin-protective effect of sesamol

作者：Srisayam Montra; Weerapreeyakul Natthida^*; Barusrux Sahapat; Kanokmedhakul Kwanjai

来源：Journal of Cosmetic Science, 2014, 65(2): 69-79.

Sesame contains high nutritional value and important bioactive lignans which are good for health-promoting effects including sesamol. Sesamol is found in trace amounts in sesame. The biological action from the trace amounts of sesamol found might indicate its efficacy. This paper presents a systematic study of the antimelanogenic and skin-protective effects (antioxidant) of sesamol and positive compounds. The results showed that sesamol had the most scavenging 2,2-Diphenyl-1-picrylhydrazyl hydrate (DPPH center dot) radical with an IC50 value < 14.48 mu M. The antioxidant power (Ferric reducing antioxidant power value) of sesamol at a concentration of 0.1129 mu M was 189.88 +/- 17.56 mu M FeSO4. Sesamol inhibited lipid peroxidation with an IC50 value of 6.15 +/- 0.2 mu M. Moreover, sesamol possessed a whitening effect by inhibition of mushroom tyrosinase at an IC50 value of 1.6 mu M and an inhibition of cellular tyrosinase with 23.55 +/- 8.25% inhibition at a concentration of 217.2 mu M. Sesamol exhibited high antioxidant and anti-tyrosinase activity compared to the positive control, kojic acid and beta-arbutin. Sesamol from edible sesame seed could therefore have an alternative cosmeceutical purpose.

• 出版日期2014-4