A Long-term Follow-up Study of 91 Cases with Ovarian Granulosa Cell Tumors

作者：Shim Seung Hyuk; Lee Sun Joo; Kim Dae Yeon^*; Kim Jin; Kim Soo Nyung; Kang Soon Beom; Kim Jong Hyeok; Kim Yong Man; Kim Young Tak; Nam Joo Hyun

来源：Anticancer Research, 2014, 34(2): 1001-1010.

• Granulosa cell tumor
• recurrence
• prognosis
• cytoreduction
• fertility-sparing surgery

Aim: To evaluate the prognostic factors of ovarian granulosa cell tumors (GCTs) and treatment outcomes in recurrent GCT cases. Patients and Methods: We retrospectively reviewed 91 patients with GCT who were treated in two tertiary Centers between 1989 and 2011. Results: Eighty patients had stage I tumors, five had stage II, and six had stage III. There were 15 cases of recurrence with a median follow-up time of 58 (3-254) months. Multivariate analysis identified greater tumor size and postoperative residual tumor as independent risk factors for recurrence. Twelve patients underwent secondary surgery at first recurrence. At a median follow-up of 50 (4-185) months from first recurrence, the 5-year survival was 60% for patients with and 100% for those without residual tumor after secondary surgery, respectively (p=0.018, log-rank test). Conclusion: Complete cytoreduction is an important prognostic factor for recurrent cases as well as initial treatment of GCT.

• 出版日期2014-2