Use of autogenous bone and beta-tricalcium phosphate in maxillary sinus lifting: histomorphometric study and immunohi'stochemical assessment of RUNX2 and VEGF

作者：Pereira R S^*; Gorla L F; Boos F B J D; Okamoto R; Garcia Junior I R; Hochuli Vieira E

来源：International Journal of Oral and Maxillofacial Surgery, 2017, 46(4): 503-510.

DOI：10.1016/j.ijom.2017.01.002

• maxillary sinus
• bone graft
• immunohistochemistry

The aim of this study was to compare the use of beta-tricalcium phosphate (beta-TCP) (chronOS) with autogenous bone grafts alone in maxillary sinus elevation surgery. The test samples were beta-TCP alone, beta-TCP mixed with autogenous bone grafts (1:1), and autogenous bone grafts alone. Twelve maxillary sinuses were grafted with beta-TCP (group 1), nine with beta-TCP + autogenous bone graft (group 2), and 12 with autogenous bone graft (group 3). After 6 months, biopsies were obtained concurrent to the placement of dental implants; these were subjected to histomorphometric analysis and immunohistochemical analysis for runt-related transcription factor 2 (RUNX2) and vascular endothelial growth factor (VEGF). The average bone formation in group 1 was 46.3 +/- 11.6% in the pristine bone region, 47.6 +/- 9.9% in the intermediate region, and 44.8 +/- 22.1% in the apical region; in group 2, values were 35.0 + 15.8%, 32.5 +/- 13.7%, and 32.8 +/- 16.0%, respectively; in group 3, values were 43.1 16.0%, 31.0 13.0%, and 46.1 16.3%, respectively. Immunostaining of samples in group 2 showed high cellular activity and immature bone; this differed from groups 1 and 3, in which mature bone was demonstrated. Thus, this study showed that beta-TCP presents the same behaviour as autogenous bone graft, which makes it a good bone substitute.

• 出版日期2017-4
• 单位Univ Estadual Paulista