Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model

作者：Ward Erin P; Wang James; Mendez Natalie; Yang Jian; Barback Chris; Wang Rodriguez Jessica; Trogler William; Kummel Andrew C; Blair Sarah

来源：American Journal of Surgery, 2016, 212(6): 1140-1146.

DOI：10.1016/j.amjsurg.2016.09.013

• Breast cancer
• Nanoshells
• Silica nanoparticles
• Tumor localization
• Nonpalpable

BACKGROUND: We aimed to evaluate the potential for ultrasound (US) visible biodegradable nanoshells (NS) as an alternative to wire-guided localization for nonpalpable tumors in vivo.
METHODS: VX2 tumor was injected in bilateral thighs of 22 New Zealand rabbits and after 5 to 10 days, 1 tumor was marked with a wire as a control and the contralateral tumor was injected with 1 mL of 500 nm gas-filled silica NS under Doppler US. Tumors were excised after 24 hours. Chisquare was used for significance, P = .05.
RESULTS: One rabbit was excluded on postoperative day 1 due to equipment failure, no ill effects were observed from the NS. The NS were used to localize and resect 100% of marked tissue, 4/21 wires were displaced (P < .05).
CONCLUSIONS: We have shown that preoperatively injected US visible silica NS can be successfully used to mark nonpalpable tumors in vivo more consistently than WL.

• 出版日期2016-12