ASSOCIATION BETWEEN A FUNCTIONAL POLYMORPHISM (-1195T > C) IN THE IGFBP5 PROMOTER AND HEAD AND NECK CANCER RISK

作者：Niu Jiangong; Huang Yu Jing; Wei Sheng; Liu Zhensheng; Wang Li E; Chang Shine; Chamberlain Robert M; El Naggar Adel K; Sturgis Erich M; Wei Qingyi^*

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2011, 33(5): 650-660.

DOI：10.1002/hed.21514

• IGFBP5
• head and neck cancer
• TNM stage
• polymorphism
• association

Background. To the best of our knowledge, no studies to date have evaluated roles of insulin-like growth factor binding protein 5 (IGFBP5) polymorphisms in risk of squamous cell carcinoma of the head and neck (SCCHN).
Methods. A hospital-based study of 1082 patients with SCCHN and 1120 cancer-free controls was performed to investigate associations between 2 functional polymorphisms, -1195T > C and -709G > C, in the IGFBP5 promoter region and SCCHN risk.
Results. We demonstrated that the transcription factor, activator protein 1 (AP-1), differentially bound to T or C variants at -1195 in the promoter to regulate the IGFBP5 promoter activity and that the C variant genotypes were associated with deferential risk of late-stage SCCHN, compared to the TT genotype, particularly for human papillomavirus (HPV)-unrelated sites (adjusted odds ratio [OR], 2.21; 95% confidence interval [CI], 1.19-4.11 for CC vs TT).
Conclusion. The IGFBP5 -1195T > C polymorphism is functional and may potentially be a biomarker for susceptibility to late-stage SCCHN.

• 出版日期2011-5