Association of Adiponectin with Hypertension in Type 2 Diabetic Patients: the Gender Effect

作者：Khabour Omar F^*; Wehaibi Suha H; Al Azzam Sayer I; Alzoubi Karem H; El Akawi Zeyad J

来源：Clinical and Experimental Hypertension, 2013, 35(5): 361-366.

DOI：10.3109/10641963.2012.732645

• hypertension
• adiponectin
• type 2 diabetes mellitus
• ADIPQO
• SNP

Adiponectin is an adipokine involved in the regulation of body metabolism and immune response. Circulating levels and/or activity of adiponectin were reported to influence susceptibility to several diseases, including type 2 diabetes mellitus, cardiovascular disease, and metabolic syndrome. In this study, serum adiponectin levels and the association of adiponectin gene (ADIPQO) single-nucleotide polymorphism (G276T SNP) with hypertension in type 2 diabetic patients were examined. Type 2 diabetic patients (n = 449) were recruited and divided into two groups, normotensive (n = 199) and hypertensive (n = 250). Results demonstrated that serum adiponectin levels were significantly higher in normotensive subjects compared with hypertensive subjects (P < .05). When these results were compared according to gender, only female hypertensive diabetic patients showed significantly higher levels of adiponectin (P < .05). In addition, no significant difference in the genotypes and alleles frequencies of ADIPQO G276T SNP was observed between the two groups (P > .05). In conclusion, high circulating levels of adiponectin were found to be associated with hypertension only in type 2 diabetic female patients which might indicate a gender preference.

• 出版日期2013