An efficient improvement on total synthesis of shikonin

作者:Rao, Zhen; Zhou, Wen; Peng, Ying; Li, Shao Shun*
来源:Journal of Chemical Research, 2010, (4): 236-237.
DOI:10.3184/030823410X12709960181221

摘要

The problem associated with electrolytic deprotection, which is a concern in the total synthesis of shikonin, is solved by the addition of Cu(2+) to the electrolysis system. The improvement has three advantages: first, it practically increased the yield from 40 to 85%; second, the isolation of shikonin became much easier. Third, the reaction time was significantly shortened.