A new portal for the analysis of human splicing variants

作者：Kroll Jose Eduardo; Galante Pedro A F; Ohara Daniel T; Navarro Fabio C P; Ohno Machado Lucila; de Souza Sandro J^*

来源：RNA Biology, 2012, 9(11): 1339-1343.

DOI：10.4161/rna.22182

• bioinformatics
• alternative splicing
• combined alternative splicing events
• database
• method of analysis
• regular expressions
• next-generation sequencing

Understanding alternative splicing is crucial to elucidate the mechanisms behind several biological phenomena, including diseases. The huge amount of expressed sequences available nowadays represents an opportunity and a challenge to catalog and display alternative splicing events (ASEs). Although several groups have faced this challenge with relative success, we still lack a computational tool that uses a simple and straightforward method to retrieve, name and present ASEs. Here we present SPLOOCE, a portal for the analysis of human splicing variants. SPLOOCE uses a method based on regular expressions for retrieval of ASEs. We propose a simple syntax that is able to capture the complexity of ASEs.

• 出版日期2012-11