Body mass index is related to microvascular vasomotion, this is partly explained by adiponectin

作者：de Boer Michiel P^*; Wijnstok Nienke J; Serne Erik H; Eringa Etto C; Stehouwer Coen D A; Flyvbjerg Allan; Hoekstra Trynke; Heymans Martijn W; Meijer Rick I; Twisk Jos W; Smulders Yvo M

来源：European Journal of Clinical Investigation, 2014, 44(7): 660-667.

DOI：10.1111/eci.12284

• Adiponectin
• BMI
• microcirculation
• vasomotion

Objective obesity-related microvascular dysfunction, including alterations in rhythmic changes in vascular diameter, so-called vasomotion', may be important in the clustering of obesity with other cardiovascular risk factors. Adipokines have been suggested to play a role in obesity-related vascular dysfunction. Alterations in vasomotion have been found using extreme body mass index (BMI) phenotypes. Whether these alterations can be translated to the general population is unknown. The aim was to retrospectively investigate relationships between BMI, vasomotion and adipokines in a population-based cohort. Methods Adiposity, vasomotion, adiponectin and leptin were determined in 94 apparently healthy participants (age 42years, 46 men, mean BMI 255 +/- 38kg/m2) of the Amsterdam Growth and Health Longitudinal Study (AGHLS). Vasomotion was assessed via wavelet analysis of skin laser Doppler flowmetry (LDF). Results BMI was associated with the neurogenic domain of the vasomotion spectrum ( -0011, P=0046), adiponectin ( -018, P=0028) and leptin ( 222, P<00001). Adiponectin was positively associated with the neurogenic domain of vasomotion ( 0016, P=0019). Leptin did not show any significant relationship with vasomotion. The association between BMI and the neurogenic domain of the vasomotion spectrum was partly explained by adiponectin. Conclusions The association between adiposity and microvascular vasomotion also applies to the normal population and is partly explained by adiponectin.

• 出版日期2014-7